An entity crosses the galaxy and finds its way to Earth, where it inhabits a preacher in Africa who explodes soon after. The same phenomenon is observed at a Satanic Temple in Russia and in a gathering of Scientologists. Meanwhile, in Texas, Jesse Custer, a preacher with a sordid past, begins to lose his faith in his church and debates leaving. Tulip O’Hare, a mysterious woman from Jesse’s violent past propositions him with a job, but Jesse turns her down. Cassidy, an Irish vampire, lands in Texas after a violent episode on a private jet. Jesse has a run-in with the abusive husband of one of his churchgoers and quickly subdues him and his friends, meeting Cassidy in the process. Jesse heads to the church to ask for a sign to continue. The entity appears in the church and inhabits Jesse. Three days later, Jesse awakens and decides not to leave the church, saying he is not quite done yet.